Is it sill required to reset your profile in the categories where it says you have to?

You don't need to reset your profile if you chose category without demons. If you run 100% you also don't need to reset.

So if I wanted to run 1-21 I'd have to reset?

If you run 1-21 100% (collect all the coins) you don't need to reset.

Actually, you can run without profile reset but you need to collect coins during the run to "unlock" demons (if you run with demon levels you need to collect 10 coins for Clubstep, 20 coins for Theory of Everything 2 and 30 coins for Deadlocked).

ah ok makes sense

So If I Do 1-14 Any%, I Have To Collect 10 Coins?

@CircleGuy yes, because you need 10 Coins to unlock Clubstep