Not only is this method 100% consistent, it also results in more points and can be performed on any computer of any strength. No more running Titan Quest on a crap computer!

so I have to shut down the game every time ? or can I run a blender under the game and just press F12 from time to time?

Run Blender under the game, click on Blender, press F12 and come back - you don't have to close the game, just click off of it.