I know some things like the vendor glitch are out but how bad would it be to speedrun fallout 4 on the newest version? if they add runs for the current version of fallout 4 I probably would start running it, I don't care if the run is almost as long as glitchless and I might even end up running glitchless anyway.

You can still run on the latest patch, it just won't have its own leaderboard.