There's inconsistencies between the older and current (2024) versions of Duckstation as of writing this, which causes the load times of modern duckstation to be slower than the older versions. But the gist of the currently acceptable settings is this: Clockspeed 130%(44.03MHz), 8 sector runahead, 2x read speed, and instant seek speedup. This is to get the emulation load times as close to PS2 with fast disk enabled as possible. Going forward, you can use the 2022 build provided in Resources, or use the modern versions despite the extra added time. But you have no real reason to do the latter unless you're just trying to make things harder for yourself :P