An updated version of the Death% speedrun category as of November 2022. (Most of this is a copy and paste of the original with minor but important changes.)

Before you start this run, make sure you're playing on version 2.1. You can check this by going into the Management Options. If it doesn't say "Version 2.0" then you're playing on the correct version. This is the version 2.1 emulator that I use: https://www.myabandonware.com/game/the-oregon-trail-2ku/play-2ku

1. Travel the trail (1), and choose any job, it doesn’t matter here.
2. Name your first party member "y", so you will already be able to buffer a "y" for "Are you sure with these names" later. You can fill in the rest of the names with stock names by pressing an extra "enter" after entering the wagon leader’s name.
3. Leave in any month, it doesn’t matter here. I have a superstition that the “extreme months” (March and July) kill people faster, but I have no significant evidence to prove that this is faster.
4. Get 1 yoke of oxen and exit the shop.
5. When you get in the game menu, press 1. "Continue the trail", and the moment that you've started moving, press Enter and spam 8. "Hunt for food." It should say "You cannot go hunting because you have no bullets." Spam 8, spacebar, and enter all at the same time. Attempting to hunt with no bullets skips the day without moving our wagon, and since we have no food, the team's health will diminished rapidly.
6. As you keep doing this, you will get pop-ups saying that people are getting sick and dying. Once the gravestone pops up, you have successfully killed everyone! Congratulations, you murderer!