To just start off, as of writing this there is no "perfect seed" found. I am currently using seed 111222222

The overall run is similar to unseeded runs, but you are left with more choices. I won't be detailing everything here, since a lot of hints are posted on the regular 50 guide and I don't want this to be too long. This seed has 6 leeks and 1 horseradish on Day 6, with Stardrop luck (assuming you don't take extra steps while sleeping to Day 6).

USE THE BEACH FARM MAP - there is a chance of a crate with 4 cherry bombs on the left side of the main farm land. Not 100% but reset-worthy if you want it.

Strategy 1 - Run the 50 mines as normal, collecting enough copper to level up to Mining Level 1 on Day 6. If you get the 4 cherry bombs, you can use them to help collect copper on Day 6 or save for final day. There is a good chance of a club in the crates on floor 24, so you can check if you want. Go back to the mines as normal the next lucky day to finish.

Strategy 2 - If you find the crate of 4 cherry bombs on the Beach Farm map, you have the option to try to 1-day the mines. This isn't easy, but the bombs do help. You'll want to try finding a club in the crates on floor 24 or 29. Those crates could also have food which you'll need. Do your best to kill enemies (with upgraded weapons hopefully) when possible to save a little energy. Use bombs on the ice floors (41-49).

Hint - Animation canceling can make killing things with the starting sword (and floor 20 sword) much faster, so don't forget that ladder finding option.

REMEMBER TO USE ANIMATION CANCELING (AC)!!!!! Saves a ton of time and makes a 1-day run much more possible to complete. Press "R", "right shift", and "delete" keys at the same time to cancel the animation of the club or weapon (takes practice to get the right timing). For rocks, try to cancel the moment the rock breaks and the sword after the enemy takes damage. You can rebind the keys BUT!!!!!!!!! it has to be 1:1. No macros or multiple keys bound to a single input. You can tape the keys down (like me) but it can be a little awkward.

Remember, club special attack was nerfed for cooldown on 1.5, but AC will help with damage. Club special - right click with club and SPAM the LEFT MOUSE BUTTON and C key to land extra hits.