As you may already know, Ndesu is the boss for chapter 2-3. I'm playing on PC and my fights with him always end in 3 rounds.
In the third round, he only has like 200-300hp left. I have successfully defeated him once (in 2 rounds) but having trouble replicating the result. Does this have something to do with FPS?
Any tips for the boss and for chapters 2-3 in general would be greatly appreciated. Thanks.
I've never been able to do it in 3 attempts. It should always be from the second time. It does not depend on the fps in any way for sure! You say yourself that you managed to do it on the second attempt, most likely you are not shooting correctly or not all bullets are flying at the target. Just practice, this moment has never been a problem for runners.
Yes, if I recall correctly you have to be at 30 fps (or at least it's significantly more likely/easier at 30fps) and be shooting him the entire time i.e. whenever possible. The time when you'd stop shooting him before the plaga animation plays and after the first cycle when the main plaga is going away, when he's stunned from a barrel explosion, and all of the other times you'd normally stop shooting to let your gun cool down matter for the two cycle. Be already aiming at the main plaga when he goes down so you're not wasting any time aiming and you can shoot it the entire time he's down. You can time your gun overheating to be when the little cutscene is playing and a bunch of little things to min/max that by themselves don't make it a two cycle, but if you do enough things as optimized as possible that's the difference between the standard three cycle and the two cycle.
Also, co-op might be different than solo because one person can change their FPS before the fight (can't remember if it's host or client) but it's been a while since I've looked into it. I think it's still possible to do it solo, but it's definitely possible co-op. Unlike the instant bus explosion which just seems to be a fairly low chance and completely random, the two-cycle Ndesu fight is just getting good plaga spawn positions during the first cycle, hoping for the best attack patterns, and then not making any mistakes.
