Boss : -Emperor's remain (the boss before going into "the end of time") : When entering the boss arena, go down at the border, it makes the boss idle, allowing you to free dps him.
-Zerrick & Harton fight (when you fight both at the same time) : Going far to the left/right after talking to the npc, makes you fight only one at a time.
-Majasa (Chapter 9 last boss) : Using portal at the center of the arena despawn both sarcophagus, making p2 easy
Portal abuse : Using your portal reset the map and sets your respawn point to it. This is super powerfull to reset aggro from mobs or setting up your respawn point very close to a boss who doen't have designated map for it's arena.
Intentional deaths : Dying sometimes makes you faster as you skip some backtracking, ex : the 2 areas before "The Temple of Lagon" and "The burning Pier".
Time rift skip : Using the portal to go back in time is faster than using the time rift, ex : "The precipice" after fighting the big worm.
Loading screen : Actions done during the loading screen will be done as soon as the game loads, which is a few seconds before it removes the loading screen. This allows you to open up the map or go in a direction before the loading screen disappears. There's also a weird bug that I can't seem to reproduce, that might allow your character to move farther than usual. (without doing anything after the loading screen disappeared)
Chapter 9 Gold : There is an npc that lets you choose between fighting him or giving him all your gold (up to 100 000g), try to use all your gold before that.
Don't always talk to npc : Some quests auto-complete, making you gain some seconds.