Hey guys, i'm thinking of learning to speedrun this game on any% but i was just wondering is it better to go with good or evil karma?

Watch Macasadia1's VOD. He has developed a very cool route that utilises both Good and Evil karma (he is Evil at the end of the run, but he does the Good karma missions for Fetch and Eugene).

If you aren't interested in min-maxing your powers and just want to stick to one the whole way, I'd say go Evil (Macasadia is just barely on the Evil side of the karma spectrum throughout his run). It's easier and faster to obtain karmic streaks on Evil.