In the next update, March QOL, Klei changes how world generation options work. This means that if something is set to "More" or "Lots", it will spawn in their respective biomes, and not spawn all over the map. That means that speedruns that were done pre-update will be very hard to replicate if at all, depending on the run. So is this just going to be something that is ignored, and all runs pre-update will have an advantage, or will they be removed?

"Also, due to Klei's aggressive and frequent patching over the course of the last year, the patch number that you are running on must also be included. This can be achieved by showing the home screen of the game before clicking the "host game" button. Patches may remove bugs or exploits that are used thus rendering some old techniques impossible on the current patch. Until someone shares a way to safely downpatch your game, runs will be removed if a used bug is removed in a later patch."

From the "Category and Rule Updates" thread.

Custom world settings runs will be wiped.