What are some glitches or moments you've had that straight up killed your runs? Here's one of mine: Big Chungus falls off the map

Sometimes save/loading just crashes the game. Mostly in Infirmary, but I've had it happen at To The Outside in the final chapter, too.

Big Chungus falling off the map seems to happen most if I start moving too quickly when the area loads in. It is tragic.

The tunnel heading back from the mines after the elevator will crash the game if you are being chased by the swarm of flies or whatever for too long

Here's another one (and this might seem silly) but the game will not stop you from binding your mouseclicks to pausing the game. While the idea is to use them to spam pauses for the boost jump glitch you actually give up the ability to click on anything in the menus (binding Interact to a keyboad key does not fix this) so uhhh as silly as it sounds don't bind pause to both left mouse and right mouse