New strat hype! Thanks to vocaab from Arcus's community, we now know that you can simply shoot the roof door open instead of needing the key! According to my loose timing under optimal conditions, it saves a little over 2.5 seconds. Since this beat my former WR with the old route by a smidge over 3 seconds, this also was a better run overall, mostly thanks to a sick floor 31 this time.
Of course, watching it back, there are still frames of leeway here and there with this route, but knowing this game and the many new runners it brings, I'm sure a new route/strat will be found that will push this time even lower. Getting a door zip to the med pack or maybe even skipping the med pack entirely is probably the next logical thing to look into. At this point, I wouldn't be surprised if we found a way to go top route on floor 35 to clip into the C4 room or some crazy credits warp/alternate unintended route.
Run on EverDrive N8.