While monitoring the value Tenerezza.exe+A24D8 for the text skipping flag (set by holding down Ctrl or the B Button), I noticed that the value is locked if you change which window is in focus. This means that the text will skip even without you holding down a button.

Steps to replicate:

Have another window—the game folder, a notepad window, anything—open alongside the game. During gameplay, press Ctrl and, at the same time, click on the other window. When you next click on the Tenerezza window, it'll behave as if the Ctrl key is still being held.

This lock can be established at any moment, even on the title screen. As a result, you can have the lock established before your run has begun.

Notes:

This doesn't seem to be broken by opening menus, moving to new areas, dying, or alt-tabbing. I need to do a full playthrough to see if anything breaks the lock, but in my brief testing, the game-exit prompt was the only interrupt I could find via Keyboard play.

The behaviour of the Ctrl key is different to a controller's button press, and sadly, this lock cannot be triggered using a controller. Furthermore, pressing the Xbox controller's B button at any point will disable the lock, so if you ever need to use the B button, you'll have to set the lock back up again after. It only takes a split second to switch to another window and back, but it'll still be a small time loss.