I've seen that some runners manipulated their save file in order to change the charms pool that you unlocked, reducing the probability of dropping unwanted charms.

Would be cool to have a guide of some sort, in the appropriate section, so anyone can setup their run equally.

Its not a modified file, just new account with proper weapons and modifications and power from pain unlocked. This leaves i think 12 unwanted charms locked and out of the pool

You can use https://uesaveeditor.cc/ to change save files

I would advise all who use the save editor to first make a copy of your original save and put it in a folder before messing around to avoid corruption