To run AS2 on AMD GPUs follow these steps:

1. Turn off fullscreen optimisations - Go to AlienShooter.exe and go to Properties, then Compatibility and tick "Disable fullscreen optimisations". If you don't do this, the game freezes on startup unless you tab in and out of game and after the intro credits, the game crashes.

2. DO NOT RUN AS2 IN COMPATIBILITY MODE - If you do, AS2 will either start with no sound, or crash.