the biggest change in full runs is that it seems you're able to cancel going to the ship after rescuing a crewmate by pressing R in non-glitchless categories, which saves a bit of time and has already led to massive improvements in the any% category which has already broken the 4:xx barrier in the new version.

in ILs, a new trick has been made possible due to a fix in how flipping off the edge of vertically moving platforms works. Particularly, Space Station 1 V-rank is now almost 1.5s faster due to being just barely able to go through a room a cycle faster, and made getting a time of 51.xx a breeze in comparison to how extremely difficult 52.xx was last patch.

in terms of timing, more accurate ingame timer should allow runs from now on to include ms in game time, which should be a massive win for those who care about IL runs like me, as a lot of categories got way too optimized for a whole second to be reasonable to save. Although the exact details of how it'll work are pending and will be decided by moderators.

I think that's a decent summary.