Thanks guys, that helps a lot!

I killed the boyle on the stairs with the springrazor, then took the note, it pointed me to a different Boyle, also killed her with a springrazor. but when she died the Samuel quest marker did not appear. This softlocked the game. This has happened to me 2 runs in a row and I'm wondering if it is something I'm doing wrong or if there is a way around it Thanks!