Pressing 'esc' during dialogue will skip it.

Collecting a bomb during the intro area will guarantee 60-70 dmg against the 'Rock Mimic' before attacking.

'Float Boots' or 'Float Potion' will get you across the bridge in 'Dungeon 4' without having to fight 'Mortar, Charged Golem'.

Use the money gathered from the 'Rock Mimic' to buy keys and gain upgrades throughout the run.