Lots of stuff was found in this run including the first sequence break (to my knowledge). This run has some poor movement is certain areas, 2:29 or lower is definitely possible.

I'm not 100% sure what is causing guard to despawn at the last segment (my guess is not switching to the belgique) but I was messing around with getting the Early Blastdoor and found a way to do just that. I was having trouble getting through without having dr.jones die after but I seem to have found something here, let me know if anyone can confirm this.

I just shoot the first guard (after dr.jones intro cutscene, grab the PS100 but keep using the P2K. Grab the armor, switch to unarmed and then back to P2K shoot the 2 guards and the one coming out of the gate and just run through. Saves loads of time and removes most of the shooting from this segment.

Also, when getting the first security card right at the beginning of the run, you can clip through the door while it's opening back up if you just open it while it's closing. (after getting the card) Seems to be only useful here and is a minor find.