ScummVM. First sub-48. Knocked 40 seconds off my previous record, partially by better execution and no silly deaths this time, but largely by switching to the French version. The French and German versions skip the Narrator's previously unskippable "Meanwhile in Sickbay" line and Roger's previously unskippable "scuff-resistant" eulogy.
Additionally a workaround has been implemented to prevent the Elevator softlock on the third visit to Delta Burksilon. When using the Transponder on Polysorbate after visiting Fester, click the top left of the inventory icon so that your cursor does not overlap the Boot Liqor entrance that lies beneath it. The Walk Cursor is disabled if you don't do this, although we don't notice it until the Elevator as we do not use the Walk Cursor until then.