I'm about to start this game, although my only experience is the GBA version I will be attempting the NES, my only question is if this game runs on framerules like SMB1.

This game does have framerules, but it's quite different from SMB1.

This game runs on framerules of 256 frames instead of 21. These affect enemy patterns, such as when pink birdo will shoot eggs which is once every 256 frames so you can make small mistakes in some scenarios and still not lose time if you don't miss that 256 frame window (cycle). The game does not wait to end on a framerule like SMB1 does. Additionally, the framerule system is not cumulative in this game. What I mean by that is that it resets at the player select screen at the beginning of every level. How quickly or slowly you beat a level has zero influence on what patterns you will get on the next level.

Hopefully that makes sense.

Thanks, I will practice and I hope I can post a run soon!