For some reason this game exists, and the main category requires you to click 10,000 times as fast as you can: https://www.speedrun.com/mnim That is probably the most clicks-per-second game you can find around here.
There is also this great category on the Cookie Clicker CE where you simply clicker 10,000 times https://www.speedrun.com/cclickermemes#10000_Left_Clicks