Since the ability to save the debug file was discovered a couple months ago by TheWayfaringFox, and the recent showing of its uses at Benstephens56's AGDQ run, the Debug File has gained a lot of interest. This post should clear up some things about how it'll be used.
Any% - Slow
100% - You ~could~ use it here, but you'd have to recollect everything, and having more than 30 hearts can make the game unstable.
All Dungeons - Not a very serious category and use of the Debug File is fun. You can (and should) use it here.
MST - Banned.
Glitched 100% - The entire basis of the category. Not called NSR due to that name being unfitting.