If anyone has any findings, post 'em here!
The reason I'm posting this thread is, while we have ColonelSanders explanation of how to replicate this glitch, it's also possible to have the glitch persist over the entire run and not just individual levels as he is talking about.
IFS persisting over several runs for LifeL1ke
ColonelSander's method of replicating this:
Save file with the glitch active:
Looked into some related memory stuffs: