I made some changes to the load remover script by DrTChops, which can be found at here: https://raw.githubusercontent.com/Som1Lse/asl/master/dishonored2.asl

I submitted a pull request so it is likely it will automatically be downloaded in the future, but in the mean time you can open "LiveSplit.AutoSplitters.xml" in notepad or similar, find where it says "https://raw.githubusercontent.com/drtchops/asl/master/dishonored2.asl", and replace "drtchops" with "Som1Lse" to download the modified script. Then go into properties, and change the file to be read only.

Alternatively download the script file, and create a Scriptable Auto Splitter in your layout, and point it to the file.

It is based on the coordinates of where you are while loading the first map, so you need to start from a save, and it needs to be at a specific spot, so if it doesn't work that might be the cause. If you open the script file, you can paste the offsets for the variables x, y and z, into Cheat Engine and see at which position your character actually is.

Here is a cheat table with the values being used in the script: https://dl.dropboxusercontent.com/u/4035066/Dishonored2ASL.CT SfxPck should be "main-game1-dunwall_escape_tower_p-sfx.pck" (without the quotes) x should be between -28.10 and -28.09 y should be between -153.97 and -153.96 z should be between 66.40 and 66.41