Little Explanation: You can walk to every point with double click, so you can skip the walking animation. Some of them are kind of shortcuts. There is a glitch which you can use. Click "i" (for inventory) and left mouse button at the same time. Rufus is still walking while the inventory is open. Normally he stops at this point.

Skip the Tutorial

ACT I

Press on the Cushion left from the suitcase and take the green sock Walk right and take the torch and oil can Walk to the living area Take the Chafing chit which is on the bathroom door. Open the door and take the plunger. Try to take the toothbrush. After that open the locker and take bolt cutter and the detergent. Open the door of Toni's room, try to walk in the room and take the severe slip. Go down to the living room and use the plunger on the closet. Take the mouse trap from the mouse hole. Use the sink, take the fork and the malicious memo. Empty the oil can in the sink. Take the bitching post-it from the fridge. Open the fridge and take the yellow sock from the inside. take the coat, you'll find the blue sock inside. Use the empty can on the sofa, to get provisions. Take the nagging note from the sofa. Put the bunch of notes in the oven and use the torch on it. In your inventory use the pot with water with the detergent. Now put the pot on the hotplate. Put the yellow sock and then the blue sock in the pot. Then use the fork on the pot to get a green sock. Combine the provisions on the mouse trap. Now try to catch the toothbrush with the mouse trap. Go upstairs and open the suitcase. Put provision, socks, toothbrush and the bolt cutter in the suitcase. After that choose the bolt cutter on the list to put it out.

Behind tonis house take the wrench and walk through the house to the front of the house. Use the wrench to take of the mailbox. Go behind the house again. Open the door of the pod and use the wrench on the seat. Put the mailbox on the base plate. Open the storage place and put the battery out. Put the suitcase in the storage place and the battery in the mailbox. Go to the control panel.

Skip the Puzzle for Any% or play it for Any% No Skip (Solution: https://www.speedrun.com/deponia/guide/r66w2 by Solid)

Use the torch on the fuse. climb the chain 3 times. Open your suitcase and take provisions and the socks. Put some provisions on the cogwheels. Block the hatch with the socks and open it. Take the maintance arm. Use the maintance arm to open the hatch on the left side and go through. No switch one lever.

Go to the village center into Toni's Shop. Skip Dialog and exit it with "5". Try to take some vouchers. Then take a hook. Go outside and into the town hall. Take the magnets and go to the assembly hall. Go from the stage to the assembly hall, press the doorknob and take the balloons. Go through the town hall outside into the alley. Use the magnets on the detonation plan.

"Magnets" Minigame is not skipable. Solution: https://www.speedrun.com/deponia/guide/r66w2 by Solid

Use the blast signal for detonation. Now go into Lonzo's bar. Take the dart and speak with Lonzo: 3 - 3 Take the red curtain and the sign. Go through the alley to the emergency station. Use the ballons on laughing gas. Now combine this balloon with the hook. Use balloons on the laughing gas again and take the dentists drill. Go outside and then inside again. Use the lever to switch to police. Take foot fetters from the police box and switch lever to fire department. Take the fire extinguisher and put the foot fetters in the fire fighter's cabinet. Switch back to police and take the handcuffs. Switch to fire department again and take asbestos gloves. Use the handcuffs with the hatch. Go outside and then inside again. Switch to police and go to the alley back. Use balloon with laughing gas with the parrot. Go from the village center to wenzels house. Skip the dialogue: 4 Go into the basement and use the dentist's driller with the pipe. Back to the living room upstairs to the bathroom. Take the sponge and put the ballon with the hook in the furnace. Go from the village center to toni's house and walk inside. Use the sponge with the pot. Go behind Toni's house and take the torch, the dud and the funnel. Back inside Toni's house use the key of first aid kit on the first aid kit. Take the tranquilizer. Go to the front of Toni's house and use asbestos gloves to take the chili pepper. Go back through the village center to the water reservoir. Kick the pipe and then use the tap of reservoire. Go into wenzels into wenzels house and take the divining rod. Go into town hall and take the waiting number from the floor. go into the mayor's office. Skip the Dialogue: 1 - 4 - 4 - 2 Use the bell, push the cushion away and take the planet's magnetic field. Close the drawer. Use the divining rod on the water emblem. Take the key of the cupboard and close the drawer again. Open the globe. Take the glass and use the key of the booze cabinet with the keyhole to open the secret bar. Take the booze. Go through the village center to the front of the town gate. Use the sponge with the windshield. Then look at it. Go up to the emergency station with the pole. Take the lock pick and open the cell grating. Go outside and inside, switch the lever to doctor. Open the doctor's cabinet with the lock pick and take the syringe. Go to the alley and speak with Hannek: 2 - 2 - 4 - 3 - 2 Go Through the village center back to the front of the town gate. Use the key of truck with the truck door and switch the lever. Open the hood. Use the dentist's driller with the battery. Use the glass with the acid to get it. Put the sign on the bulletin board. After that use the red curtain on it. Use the syringe on the bull to get the taurine. Combine the booze and the syringe with the glass to get energy-rich, revitalizing and clear water. Combine first the dart with the tranquilizer and then the dart with the funnel. Now use the dentist's driller with the dud to get black powder. Go to the village center in front of Toni's shop. Use the blow pipe with the window. Go into Toni's shop and take the vouchers. Use chili pepper, black powder and stimulant with the grinder. Use the crank once and open the grinder. Take the coffee powder. Go back to Lonzo's bar and use the coffee powder and water with his machine. Use the espresso with the parrot to wake him up. Go through the town hall to the assembly hall on the stage. Use the funnel on goal. It will not work but it's neccesary. Go down from the stage and use the torch on the cardboard box. Go up to the stage and take the stethoscope and put it in the bag of the mayor. Now use the funnel and the espresso on goal. After cutszene leave the dialogue: 4 Go back to Toni's shop and put the parrot on the pole. After leaving go back inside and take the parrot back. Go outside to the village center and put the parrot on the emergency phone. Go to the assembly hall in the town hall. On the stage take the mayor's clock and the microphone. Back in the town hall use the clock with the "opening hours". Go into the post office. On the right side are two hatches. open the left one and use the tranquilizer with this cat. Open the other hatch and use the espresso with this cat. Now go upstairs to the operator's platform. Use the planet's magnetic field with the cupboard to put it in

Skip the "Birds" puzzle for Any% or play it for Any% No Skip (Solution: https://www.speedrun.com/deponia/guide/r66w2 by Solid)

Go back to the postoffice and give a voucher to the postbot. Then walk 3 times over the bubble wrap. Go back to the post office. Open the Replacement Cat's hatch and take the cats. Take the note and use following code on the clock face: 3 6 4 9 Take the nodding bird an go to the mayor's office. Use one cat for the teletypewriter and the nodding bird on the communicator. Go to the operator's platform and take the headphones. Back in the postoffice use the headphones and microphone on the radio to speak with cletus: 1 - 2 - 2 Go back to the emergency station. look at the bed sheet but it's a trap. Use the cat with the tree to escape. Go to wenzels house and then into the basement. Open the cupboard and then use the divining rod with the basement door.

ACT II

Go through the tunnel. Use the minebike and take the halogen lamp from the headlight. Continue to the viaduct. Speak with Doc: 1 - 1 - 3 - 1 - 3 - 5 Go back to the tunnel and use the avial power inverter with the minibike. now go the junk heap.

Skip the "Power Inverters" Puzzle for Any% or play it for Any% No Skip (Solution: https://www.speedrun.com/deponia/guide/r66w2 by Solid)

Use the dorsal power inverter on the minibike, use it and set off. Use the switch. Go back to the tunnel. You're on the top. Use the Lever and then the button. Go to the viaduct. Take the key and a part of the skeleton. Go back to the tunnel and push the lever. Go into the control center. Use the key of the trackman with the key box. Take the wrench and the cloth. Set off with the bike again but this time dismount without using the switch. Go to the viaduct. Try to take the booze. Then use the cloth with the booze. Go to the outer Turn. Take the mirror and clean it with the cloth with alcohol. use the halogen lamp with the signaling light base. Then use the wrench with maintenance hatch. Take the fuse and put the bi-nausal power inverter in the maintenance box. hang the mirror on the skeleton. Go to the tunnel and switch the lever. Go to the viaduct and then to the outer turn. Take the bottle and the lever. Go again to the tunnel and use the lever on the shunting lever box and switch it. Drive the minibike to the crane. Walk to the crane and open the maintance box. Switch the defective fuse with the functional one. Now use the crane. Go back to the viaduct and talk to Doc: 3 - 1 Use the bottle with the booze. Now look at the horizon. Go back to the crane. Put the leg of the skeleton on the seat. Look at the Horizon and choose "PUPUP" Now drink some from the bottle and use the crane again. Go fast to the tunnel and back to the turn. Use the minibike and set off. Then use the switch.

"Switches" Minigame is not skipable. Solution: https://www.speedrun.com/deponia/guide/r66w2 by Solid
Short press following
Red lever 1x, left switch 1x, right switch 2x. 
SET OFF!

ACT III

Use the anchovy machine, take the anchovy and eat it. Use the machine again and take the second one. Open the shelf and put the plug in. Push the lever two times and use the stick with the cotton candy machine. Use the chewing gum dispenser and eat the chewing gum. Go through the lobby to the concourse. Take the mosaic stone. Then use the phosphor cotton candy with the lamp. On the right take a pebble. Go to the evelator. Go to the platform but it won't work. Open the utility cabinet and take the mop, soap and bucket. Go back to the lobby and on the left to the tower. Use the bucket with the barrel with the water. Combine soap with water and mop with the bucket. Now combine the chewed gum with mosaic stone. Go back to the concurse and clean up the dirty mosaic table with mop and the soapy water. Put the glowing phosphor cotton candy in the hatch and use the mosaic stone with the hole.

Skip the "Mosaic" puzzle for Any% or play it for Any% No Skip (Solution: https://www.speedrun.com/deponia/guide/r66w2 by Solid)

After the mosaic window is broken, take the mosaic stone from the floor. Open the fusebox, take the torch light and use the fuse switch. Use the Controls and you will go to the platform. Switch the lever and take the flag. Then take the embellishment. Go down to the elevator and use the mop with the oil tank lid. Go to the concurse. First combine the chewed gum with the embellishment, then the pebble with the slingshot. Use the slingshot with the lamp. Combine the embellishment with the mop handle and take the lampshade with the hook. Use the flag with the lampshade and then the greasy mop with the Organon GetUp. Change your clothes and speak with argus. Go up to the platform and speak with cletus: 2 - 5 - 4 - 4 - 3 - 3 - 2 Go through the concourse with the improvised cletus costume back to the candy shop. Use the anchovies on a stick with the puddle of phosphor. Use the torch light with the anchovie and then the torchlight with the puddle. Outside use the torchlight again with the phosphor trace until you're at the tower. Open the piece of fence on the right side and go through it. take straw from the stack of needles. Now use the hook with the grating. Go into the cable chute. Put the glowing bait on the hook and go to the wrecked cable boat. Then go into the boat. Skip dialogue and take the dataset cartridge from goals head. Take the duster and the key and go outside. Open the box with the key and look what's inside. Use the steel brush with the cartridge.

Skip the "Clean Cartridge" puzzle for Any% or play it for Any% No Skip (Solution: https://www.speedrun.com/deponia/guide/r66w2 by Solid)

Skip the dialouge: 6 - 3 Go all the way back to the front of tower. Use the straw with the pool. Go through the trunk. Go to the left window and use the crank. Go to the french door and take the fork. Go to the Pipe, put the fork inside of the horn and use it. Go through the canopy top. Walk over the platypus soft toy. If you're fast enough you can walk over it again and walk to left side. (Normally you go left. take the toy, go right, put the toy under the plank and walk over it again.) Go to the crane and use the crane lever. Skip the discussion between cletus and goal: 4 Go to the bag and take cletus' Rags and change clothes. Talk to the squabblers: 3 Take Cletus' speedos and put it on the flagpole. Take the cartridge from goals head. Speak with goal: 2 - 2 - 2 - 2 - 2 Go back to the concourse and take the cartridge. Go to the elevator and speak with cletus: 3 Switch to the Ramp on the right side and try to reach the right handle. You will fall. The dialogue with Bozo: Choose any - TIME!