For all categories, I think it should be required for "Clear Save" to be used before every run to reset quest and pack progress.

For All Packs and Cardopedia it goes without saying, but for Beat the Demon, it should be clarified.

Starting with every pack and idea cards removed from pools can change the routing significantly. Plus, I think it's more interesting to need to take quests into account for runs.

Good point, I will add the rule to clear up any possible confusion