I was just wanting clarity on run submission. Are these runs "New Expedition +" or are they supposed to be new runs from 0?

Both Any% and 100% Category rules specify that they have to be done with a new save file. Chapter runs can be done with any meta progression.

Thanks for the quick reply. I totally missed the other chapter headings on first view.

What is the purpose of the double load used in any% when the first boss during chapter 4 appears?

/edit

I just realised it might stop the power up buildings from spawning? When does the game save, or is it glitched somehow so the game never loads a real save? It's a very confusing trick haha