I tried my hardest (with mousekeys and ingame autostorm) to get the most clicks per second and my max was 38 clicks per second. I'd say that is the most a player could do, so I am voting for showing the stats screen after the run and thus minimizing the potential for people who use autoclickers.

did you use double autoclicker enhancement? I was able to make 30 clicks per second without a game autoclicker, and with doubled game capabilities, the statistics will have 50 clicks per second at the peak