I've written a quick script to save edit all Vault Card Challenges to be complete, so you don't need to worry about them when doing runs. This script requires you to install Python 3, and Apocalyptechs Python Command Line Save Editor.

1. Download the latest Python release from here.

2. On the first screen of the installer, make sure to tick the box to add it to your PATH:

3. Work through the rest of the installer. If you customize the installation, make sure to install pip.

4. Open up a terminal (command prompt/powershell), and run pip install bl3-cli-saveedit.

5. Download complete_vault_card_challenges.py and put it into your saves folder.

6. Make sure the game is closed, then simply double click and run complete_vault_card_challenges.py.

Your save should now have all challenges permanently complete - you don't actually need the script for anything anymore.