This is something I'm not sure yet if it would work, but we need to do some testing.

In order to access one of the fragments, you need to activate the Map.

During one of my runs, I was able to skip the tutorial accidently, probably by spamming the M key. I thought at that time I would get a huge timesave.

The problem (Which you won't see in the clip below) is, when I collected the last key fragment, and when the pop-up for the Synthesized Key appeared, the game, instead of letting me press any key to close the pop-up, invited me to press M key, to do the Map tutorial. Ultimately I lost time, so I resetted.

Maybe there is a way to skip the Map tutorial the first time, and then a second time when you have the Synthesized Key pop-up spawning. Maybe spamming the M key correctly in both instance would make it doable, and make this skip viable.

This are some theories I'm posting here, in case some people want to investigate that case. I'm not sure I'll be able to test it soon, because I have other routing work to do on other games.

One last bonus thing, unrelated to this potential skip: I was able to skip a ledge grab once, during one of my attempts. If we can find a way to understand how it works, and make it somewhat consistent, it could be a way to save few seconds in the entire run (For such a short run, we have to take all possible time saves!).

Here is the clip of when the skip happened: