Decided to bring this up to everyone. Currently an unofficial run, status may change in the future. Posted with permission from Szoren:

My thoughts so far:

• Running-wise, looks really fun to do.
• Rule-wise, unsure. Notice after finishing each character (defeating Ducan Commander, first one at about 7:30) there is a cutscene and a few screen flashes before going back to the main menu. This could bring up the issue of splicing.

All potential ideas and solutions are welcome.

Update after talking to a few mods from other games. Here were some things that they recommended to take a look into.
• Audio blips
• Load times/transitions
• Score/collectibles

Will be taking a look into this soon. Feel free to post any findings in this thread!

Shoutout to @GproGpro, @LafungoLafungo, and @stllrstllr!

Hey folks, closing the thread now! Please review the new submission rule, thank you!