I have a question about Rebinding keys. A runner found out that closing the game with Alt+F4 is faster than doing it with a mouse. My fingers can't hit both keys at the same time, so I was curious if it was allowed to rebind the keys (not to macro) so that I could quickly close the game.

with "hitting both keys at the same time" do you mean like pressing alt + f4 at the same time or holding alt and then pressing f4 at the right time?

Keep in mind some people might have injuries or disabilities that prevent them from hitting what are honestly two fairly far-apart keys.

The runner is asking if they can press Shift + Z instead of Alt + F4, so 2 buttons still. In most speedrun communities, this is allowed Runner is NOT asking "can I press the Z button to do an ALT + F4"

Buttons are merely an example.