well, D'Sparil is an ass, and how much he teleports around can make or break the entire run. So best to start with E3 and reset if the fight goes bad. It would be nice to do the run in chronological order of the episodes, but things like that are often sacrificed for the sake of efficiency when speedrunning

There is a pair of specific skips on III episode that can be hard to pull of, and if they work out in 1 attempt then rest of speedrun would be like walk in a beach...