Well, The Last of Us, but if you mean a game that I play with any regularity, surely Binding of Isaac. That will likely fall from the "don't speedrun it" list sometime soon~ish though.
Dark cloud its my favourite game ever. Also the first game I ever seen speedrun it was awesome I was so amazed :) idk if I could ever run it maybe when I get more in to speedrunning right now I can just admire every new run :)
Metal Gear Solid 5: The Phantom Pain.
Love the game. Never want to run it.
Pokémon B2W2. I've played through that game so many times (nuzlockes and just out of boredom) that no other game gives me the same feel anymore.
Obviously never want to run it, it's a Pokémon game. Pokémon runs are literal torture.
Grand Theft Auto: San Andreas. Amazing game, awful speedgame.
Alternatively, Fallout: New Vegas, which I may end up running if I can get a good enough computer to do so.
The legend of zelda ocarina of time, such a good game but way too hard to speedrun.
Most of my PS4 games. If I really like the game (like horizon, gow, the witcher) I take all the side quests to have as much as it gives me.
And of course Dota 2! Spending most of my free time there as I really wish to join the big eSports scene someday. Like, have you seen how much pro players earn? If no -- you should check this out https://dotabetz.com/players/. Guys became millionaires at the age of 20 and that's super cool.
Please stop necroing. There's plenty of more recent threads you could reply to.