Yo, so I'm generally not a speedrunner (and to the extent I AM one I'm really not all that competitive or active) and I currently zero interest in running this game myself, but I was mucking around with the IRL in pro mode and wound up killing the Dos Gigantes in Chapter 11 with a single shot. Dunno if it'll actually change any runs (I doubt that the NG runs would have the money routing on Pro for an extra rocket launcher at this time, and I don't know if this is already a thing in NG+ runs) but I figured I'd let this community know because at the very least I found this funny when it happened.

You can find the clip I made of it when it happened here:

Looking at the footage, I just barely hit the left side (player's right) of the armored one when I did it. Don't know how easy or consistent this'd be, but (A) if it is, it's faster than killing them one at a time, and (B) if it isn't it's still funny.