Just thought I'd add this to help anyone that is unclear about how to delete your old save file and also to show anyone who needs to know what the game looks like when you start from a fresh save as opposed to when you start with a file already saved.

Basically, you know it's a clean save if after launching the game and waiting for it to load, it opens on the settings screen instead of just going straight into the first room and you can see what that looks like if you jump to 2:23 in the video. Decided to leave the early parts of the video for comparison purposes and in case someone needs instructions on how to delete their old save file.

Maybe a silly question, but if a 100% run ends up being faster than an any% run (which is possible, since getting the 6 items can be easily done during down time) does it count for both?

Assuming upgrades are fair game on any%? Specifically I'm thinking fire hose for the vine levels and sniper rifle to eliminate climbing to some objectives.