So I have known for a while that this game has Sega Mega Mouse support, but for some reason I couldn't get it to work on my actual console. I have a Model 1 Genesis and a Model 2 Sega CD. From the videos I've seen that have proven the mouse to work, they all are using the Model 2 Genesis instead. Perhaps the Model 1 is incompatible...

So I figured I would try to get mouse support working in an emulator, and RetroArch has that ability. The original Mega Mouse has three buttons to press A, B, and C, as well as a Start button, but you cant seem to bind these keys in RetroArch at all, so I mostly use the mouse for cursor movement, and keys A, Z, X on the keyboard for A, B and C on the Genesis. (these are the default binds which can be changed).

From what I've noticed, the DPI cannot be changed, so the mouse moves very fast. I adjust the DPI on my mouse to make it easier to use (I set mine to about 400).