Up above this room in Creepy Crawlies 2 is the entrance to Lab 1. Normally to get up there, you need to get the Soap invention from the Basement, which makes Bats spawn here. You Soap the Bats and then jump up them to the entrance. (We call it Redbeard Skip because in order to get into the Basement intentionally, you need to fight Redbeard and get the Gum invention.)
You can skip doing all of this by jumping onto the box in this room and then jumping up invisible walls. There is collision just above the box and on the wall below the door to Lab 1. This can be done with or without Umbrella.
Cutscene Skip: When you run into this room, a cutscene will play showing the entrance to Lab 1. You can skip this by Charging into the room and touching the Magnifying Glass as the cutscene starts. This allows Scooby to move during the cutscene, but the camera will still pan to the entrance. Runners used to attempt RBS blind while the cutscene played, but it was discovered that you can just jump towards the wall under the entrance to Lab 1 and it will reset the camera back to Scooby, completely skipping the cutscene.
Explanation
This video explains the details of RBS.
Example
Here is what it would look like when done optimally. This is the clip used in the explanation video listed above.
Tutorial
Starting from Time Stamp 2:50 in this video, you can see an explanation on how to do RBS and Shaggy Skip, the trick leading up to it.
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