Unfair Advantage: The use of an auto clicker or external program gives people unfair advantages over others who are playing the game without using any assistance. This goes against the spirit of competition and fairness that is integral to speedrunning. This also includes the use of remapping certain actions to different buttons such as mouse scrolling is left click

Bypassing game mechanics: Some auto clickers and external programs can bypass game mechanics such as cooldowns or resource management. This can significantly alter the gameplay experience and can result in faster times that would not be possible without the use of these tools.

Skewing results: The use of auto clickers or external programs can skew the results of a speedrun and make it difficult to compare times fairly. If some players are using external tools and others are not, it can be challenging to determine who is truly the fastest.