The modifiers add a lot to the game, but this also adds more to potential run variants. To start I'm having Glass Cannon, Budget Cuts, and Gun Runner setup as they are all either very different, or increase your damage output significantly. I have also added combinations of those three subcategories.

However, there are ones that make the game harder like Ace Training and Double Time. For now I feel like that since they would be slower than a No Modifiers subcategory, that they can be placed into the other subcategories if you wish to do multiple modifiers.

For example, a run with Gun Runner, Cordium Interference, and Double Time would be just in the Gun Runner subcategory, as the latter modifiers don't help you complete missions faster.