In the original game, there are many places where you can choose between multiple answers and, since you can skip the dialog, it doesn't matter which option you choose.

With the new graphics in the special edition, though, you can't skip the dialog, so which answer you choose matters because of how long it takes Guybrush to say it and because, depending on your answer, you might be able to skip the rest of the conversation by holding backspace.

But, first, let's talk about a couple of things that make the list of answers unique when using the new graphics.

Just like in the original game, you can use numbers to select the answer. However, when you press a number you're not technically choosing the answer based on the order you see on the screen; you're choosing the answer based on the order of the answers when playing with classic graphics. Most of the time, the results will be identical since the answers will appear in the same order with both classic graphics and new graphics. There are a couple of exceptions, though:

• When talking to the Fettucini brothers, the option "Of course I have a helmet" is shown first, but you have to press 2 to choose it.
• In your first two insult fights, the option "My name is Guybrush Threepwood. Prepare to die!" is shown third, but you have to press 2 to choose it
• From your third insult fight onwards, the option "My name is Guybrush Threepwood. Prepare to die!" is shown fourth, but you have to press 3 to choose it
• In the conversation with Bob, the option "I've got to go after them!" is shown second, but you have to press 1 to choose it

However, there's one advantage when using the new graphics: you can use the Enter key to choose the currently selected option, and you can use the arrow keys to select a different option. This is useful when talking to the head and when talking to Elaine at the end, since in these cases you can't use numbers to choose answers.

Note that, for the most part, pressing Enter is equivalent to pressing 1, since the first option is selected by default but, as mentioned earlier, the conversation with Bob is an exception.

Considering all that, here's a list of the fastest answers (note: this list doesn't include the negotiations the long conversation with the cannibals, since I'm not sure about that one):

• After using the cannon, answer "Where's my helmet?" (option 2).
• When Fester asks about the idol, answer "It belongs in a museum!" (option 3).
• When you go to fight the Sword Master, say "I beg your pardon, I must talk to you" (option 1).
• When you first visit Stan, answer "Let me see the best ship you've got" (option 1).
• When talking to the lookout after LeChuck takes Elaine, answer "Where did they go?" (option 2).
• When the storekeeper asks you about your job, answer "To be honest, sir, I'm between jobs" (option 5).
• After buying the ship, say "Have you come to be on my crew?" to Otis (option 3).
• When Carla asks you whether they're getting paid, answer "Glad you could make it, Carla" (option 2).
• At the beginning of the last part, say "Want to see a neat trick?" (option 3) to the ghost.
• When entering the church, say "Elaine!" (option 3).
• When talking to LeChuck, say "Please don't kill me" (option 2), then "How did you manage to escape?" (option 1) when Elaine shows up, and finally "Take THIS, you vaporous voodoo vermin!" (option 4) after Elaine leaves.
• When talking to Elaine at the end, answer "Sure" (option 1, although numbers don't work here) and then "It's not the size of the ship..." (option 2, although numbers don't work here either).

Last but not least, during the conversation with Stan, it looks like the solution by MilkToast (walking away twice and then offering 2000, 3000, 4000, 5000, and 5000 once more) saves about 30 seconds compared to the solution of rejecting 6 extras and walking away once.

Hope this helps! Please let me know if I've missed anything.