This is the Guide for speedrunning Bacteria in cure mode. Evreything related to Mega Brutal in the Bottom

Tip In cure Mode, when rushing the cure always start in a wealthy Country surrounded by many wealthy Countries unless you can get a lot of wealthy countries investigated easily. Thsi helps with the cure due to an higher contribution to the cure. Go to settings and turn autopause game off. This is leads to faster Times, enables you to stay in the control tab the whole time and also great with Procurement Director. (In Main game Metabolic Hijack)

Main Strategy For Casual to Brutal: Rush the cure For Mega Brutal at the Moment my Strategy is very much improvable. It is at the bottom.

Advisors Casual and Normal Forensic Checkpoint Enforcer (or any else, even none not slower) Strategic Fundraiser (other if too much Authority loss) Fast Response EMTs (if too much Authority loss Crisis Manager) Procurement Director (or any else)

Brutal Forensic Checkpoint Enforcer (or any else, even none not slower) Technical Officer Crisis Manager Procurement Director (or any else)

The Strategy Casual, Normal and Brutal

Before starting get: -Investigate Outbreaks -Government Partnership -Deploy Field Operatives

Start: Germany (other read below)

Start in a wealthy Country surrounded by many wealthy Countries. Or be able to investigate as many wealthy Countries as possible

After starting as soon as possible -Vaccine Research

Then get -Accerated research

Travel to the origin country of the Bacteria found under Control as soon as you can

Then get -Field Research

As soon as possible get -Vaccine Manufacturing -Accelerated Manufacturing

Next get either -Global Research Traity or -Global Manufaturing Traity Then the other one after.

Now there are multiple options: -Further speeding up research and/or manufacturing
-Decrease Infectivity
-Focus on decreasing Authority loss (This is necessary in Brutal)

Multiple Options at once is theoretically the best

Further speeding up research This done by getting any of the following: -Convalescent Plasma -Advanced Antibiotics -Monoclonal Antibody Treatment (Requires Convalescent Plasma)

Further speeding up manufacturing This done by getting -Improve Supply Chains

Decrease Infectivity Either Lockdown the Continents with many infected or in Response tab the upper options.

Focus on decreasing Authority loss Get -Authority 1 If necessary -Authority 2 -Authority 3 or if the manufacturing is almost done -Censorship (can kill runs if done too early) followed by -Fake News

At this Point my Runs were all distributing the Vaccine or nearly finished Manufacturing.

The Victory screen appears after the Vaccine begins to be distributed and there are 0 infected.

This is the end of the Casual to Brutal Section.

Mega Brutal (guide by The Overmind and link to original https://plagueinc.fandom.com/wiki/Strategy_Guide/Bacteria_(Cure_Mode) )

It is similar to my Strategy, but it is more detailed, it is written more general for the use with other diseases and it is better than I'll be able to do in the next couple of Months due to being bad at languages (English is my best Language, but not my first Language meaning I won't be able to formulate easy understandable guides as good).

Advisors For Disease Advisors Forensic Epidemiologist is best, increasing Vaccine Research Speed. The other 4 are useless for this strategy, at least against Bacteria, because we are just going to let the disease spread to every country, and Bacteria does not need to be analyzed.

For Field Advisors Crisis Manager is good, slowing Authority loss where you are deployed. Another option is Fast Response EMTs to increase the Field Operatives travel speed. The other 3 are useless for this strategy, because Non-Compliance is completely irrelevant in this strategy.

For Quarantine Advisors it doesn’t matter, all 5 of them are useless in this strategy, pick anything. They all involve Quarantine actions and Non-Compliance which are irrelevant in this strategy. Personally I went with Celebrity Scientist since that seems like a generally useful one for strategies that do involve Non-Compliance, as it simply reduces Non-Compliance without altering the actions of governments like the others.

For Operation Advisors Medical Coordinator is probably the best choice, to reduce Authority loss from Panic, although the others are valid choices too.

For Outbreak Advisors Technical Officer is definitely the best choice for this strategy, to reduce global Infection rate, and the main focus of this strategy is reducing Infection rates. Don’t choose Regulation Enforcer since we won’t do any Lockdowns, it is irrelevant.

If you don’t have all these options, it is not a big deal, you can probably still win anyway, especially if you are on an easier difficulty mode, but you probably want to get all of those Advisors before doing Mega Brutal.

Alright so now start the game with those Advisors (or the best you could do).

Now go to the Operation tab of the Control menu befor clicking on the start bubble, because this does not count towrads your time, and get Investigate Outbreaks, Deploy Field Operatives, and Government Partnerships. This should use up all your Resources.

As far as what country to be your HQ, this is not very important, but you probably want something centrally located on the world map so that when you find out where the outbreak actually is, you can get there faster. Egypt is right in the middle of the map so start there.

Go back to the map and wait for the disease to be detected or red dots to appear on the map. Once that happens, go to the Control menu and see if the Origin Country is known yet. If so, go there using your Field Operatives. If not, guess which country it started in, by looking at which countries have red dots and picking the one that seems to be in the middle. After you do this, check in the Control menu for the Origin Country again if you didn’t get it the first time, and once it shows up, send your field operatives to the Origin Country.

OK, now it is time to get serious about combating this disease. We do not care about Compliance Risk at all and will not be doing any Quarantines, and Fatality Rate is a much more minor concern than Infection Rate. The main focus is Infection Rate. Also we need to research a Vaccine and manufacture it.

But the top priority at the beginning is Infection Rate. Immediately invest in Infection Control in the Operation tab so that your Field Operatives fight infections instead of spreading them.

Then go to the Response tab and invest in things on the top side, not the bottom side, things that reduce Infection Rate, as well as Contact Tracing.

I suggest first doing Contact Tracing 1, then Hand Washing, then Disinfectant Supplies, then Public Awareness, then Self-Isolation, then Contact Tracing 2.

After this, save up enough Resources to you can start Vaccine Research in the Operation tab. Then when you have enough Resources, get Field Research, while you are still in the Origin Country. Next, start up Vaccine Manufacturing.

Now go back to the Response tab and get Border Monitoring, Testing Capacity 1, and Social Distancing.

Now go to the World menu, Data tab, Infection Spread Summary, and see which country is the most infected. If it is not the country your Field Operatives are in, move them there. From now on, you should regularly check the World menu, Data tab, Infection Spread Summary every so often and send your Field Operatives to the most infected country on a regular basis, from now until the end of the game.

Now in the Response tab of the Control menu, get PPE Package 1, Contact Tracing 3, and Testing Capacity 2.

Now in the Operation tab of the Control menu, get Accelerated Research and Accelerated Manufacturing.

Now is a good time to check if another country has a higher infection rate than the current one under World menu, Data tab, Infection Spread Summary, and send your Field Operatives there. From now on, please remember to keep doing this regularly yourself.

Next in the Response tab of the Control menu, get PPE Package 2, Contact Tracing 4, Testing Capacity 3, Mask Wearing, Improve Supply Chains, Surge Protocols, New Infrastructure, and Local Lockdowns. You might actually win the game before you are able to get all of these, depending on the difficulty level.

You should be able to win the game easily now if you remember to keep sending your Field Operatives to the most infected country. Once it says “Releasing...” you are basically a winner.

If you experience dangerous levels of Authority loss, you can get Authority 1 on the Operation tab of the Control menu and further options things to boost your Authority after you get Authority 1 such as Authority 2, Censorship, Authority 3, and Fake News. If Authority runs out, you lose the game, but this should not happen with Bacteria and this strategy. Also, since Non-Compliance is not something to worry about in this strategy, it is perfectly safe to use Censorship and Fake News even though they increase Non-Compliance, which is bad in strategies where Non-Compliance actually matters.

I hope these Guides helped and please don't credit me for the Mega Brutal Guide. I did not write the Mega Brutal Guide and don't want the credits for it. The only Credits I deserve is for Casual to Brutal Guide. The Mega Brutal Strategy is a widely used strategy found as no Lockdown Mega Brutal Bacteria Cure Mode on the internet and Videoplattforms.

Replays Casual to Brutal For Casual Willops Replay is better than mine Just watch my Runs or any other Runs close to my Times in the category.

Replays Mega Brutal The People who executed the Mega Brutal Strategy better than me are easily found on YouTube. The Link to the Person I got inspired by doing the strategy is: My Run for Mega Brutal does not deserve to be watched except for seeing my altered Execution.

Credits to -K 2 inspired the Srategy for Mega Brutal -The Overmind for the Mega Brutal Guide -Willop for making me push my Record for casual to 1:20