Are runs invalidated if I edited VTF files to make the textures on cubes, buttons, doors, turrets, cameras, and portal gun different?
Also, if I used the "Portal Tools" tool listed in the resources tab on this site, does that ruin the run?
All of those texture changes are allowed so long as they are not advantageous over the original textures. The only changes that are, as a rule, banned are texture changes to the walls or floors, and changes to the models, since they can affect the mechanics of the game.
It was recently discovered that it is possible to set your mouse sensitivity to a value so high that the game considers it infinite, leading to several new glitchy techniques being discovered.
The rules have now been amended to ban these new techniques in both Inbounds No SLA Legacy and Glitchless.