UPDATE The Smith's rescue cutscene skip found by @G_Nexus The cutscene lasts 19 seconds. Now you can skip it by killing Smith You need to shoot him and immediately (before he dies) press the action button (just spam it) Pay attention now to:

• you need to kill the Red Dragon at the entrance and hide his body (about +3-5 sec)
• you will have another 5k penalty

Now the timings are something like this:

1. Brothel - 2:00
2. Storage - 2:13
3. Guards HQ - 2:33
4. VIP - 3:00 WR of this mission with grinding the safe - 1:09