Not entirely sure what the causes of the crashes are. I had the same issues in multiple different spots, being as early as the second mission in the game and as late as "He Lives" (the keith david mission). Could be a matter of the game overloading with too many sprites going on in the game or something of that matter. I noticed that the less inputs I do the less likely it is for the game to freeze. I have been able to make it through full runs w/o any type of freezing, but don't really know what causes it/how to fix it.