Hey (sorry for taking so long), Bonezone makes the skeleton have 100% chance of throwing big bones and changes nothing else on the game. To patch it youll need a program that applies IPS patches (like lunarIPS: https://www.romhacking.net/utilities/240/) In terms of how the run would go (and believe me I kinda wanna get something and I believe some other runners also do) its the same as a regular magician mode run, except you can go for riskier strats since you can guarantee perfect bone RNG

Also glitchless compared to no OoB would just be more boring. No point for that