All help appreciated! I can make saves but when I go to load them they've disappeared!

Go to the game folder and look for the bio3 file, now look for save = and there you paste the address where you have your game in my case it would be

save = C: \ Users \ Gonza \ Desktop \ New folder (6) \ BIO3 SIMPLIFIED CHINESE

iirc I had to run the game as administrator to get saves to actually save.