If you're ever curious which orb may be the most important in any Peglin playthrough, particularly in a NoRelic% attempt, the dagger is definitely your go-to orb.
If you can get it upgraded to level III (3) over the course of your run, you'll stand in good stead to beating the final Slime Boss, especially if you can get your hand on multiple.
The best part is when you can hit crit pegs with a dagger in hand. A level I (1) daggorb will do 7 damage per peg but a level III (3) daggorb will do a whopping 13 (!) damage per peg. The difference between these is staggering the more pegs you are able to hit per shot. Let's say you've hit 7 pegs with your daggorb: your base daggorb only hits for 49 damage but if it's upgraded to level III (3) you can hit for 91 damage.
Keep this in mind the next time you are contemplating which orb is worth upgrading!