I'd like to share some tips I got while grinding the speedruns, mainly focused on relics, but also on other good to know info. This can both be used on bonusrelic% and any% glitchless.

What i've found to be the most optimal way of going both runs is getting everything related to bombs, if by the end of Act 1 you are not presented with Sapper Sack, a reset is welcome.

That said, your Act 1 go-to relics are Bomb Baton (more bombs), Powder Collector (bomb generation), Improved catalyst and Short fuse (both of them are GOATed, the former giving you more early game damage, enough for 1shot the slimes and the latter to 1-shot the bombs). You can try to fight an elite to get Bombulet as well, but that's very risky.

Other good relics for Act 1 are: Bad Cheese (the 25 AOE dmg while reloading is very good), Salt Shaker (if the boss is the slime, which is the prefered), Refreshing Punch (AOE peg destruction helps on triggering bombs and crits) and Eye of Turtle (this one is for consistency if you are resetting too much because you are not getting Sapper Sack at the end of Act 1.)

Enhanced Gunpowder can be a blessing or a curse, it helps clearing Act 1, but from Act 2 onwards, it is very dangerous to explode all of the red bombs at once (lost a couple of good runs because I killed myself).

From Act 2 onwards, your focus should be on getting HP regen/raw HP relics, such as An Apple A Day, Super Boots, Popping Corn and Wall Chicken. Also, if you don't have any bomb increase relics (Baton/Collector) you might find some rooms very hard on Act 2.

Speaking about the orbs, my go-to orbs for the whole run are Infernorb (1shot bombs), Bouldorb(aoe), Orberos(massive damage), Ball Lightning(aoe that hits bombs) and Icircle(aoe), the rest is a hard ignore for me. Matryorshbka is considerable, but very dangerous when you have lots of bombs on the board.

About preferable bosses, for Act 1 is the Slime for sure and Act 2 is the ballista guys, but careful as they hit hard.

For the board, you are aiming for something like 4 enemy encounters tops on first Act, so some luck is needed here, WR pace for finishing Act 1 is something around 48 minutes and 1116 minutes Act 2, always depending on the boards.